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This Phase 1, multi-center trial is a two-part, open-label clinical trial with a Dose Escalation Segment (3+3 design) followed by a Dose and Disease Expansion Segment. A total of approximately 50 subjects will be enrolled in participating centers in Australia. doctor home loans Oak Laurel 0430129662 oaklaurel.com.au The first patient was enrolled at Linear Clinical Research in Australia. We are very excited to commence dosing on the first-in-human trial of CBT-501, which has been specifically developed with improved characteristics over existing PD-1 inhibitors, said Professor Michael Millward, lead investigator at the Linear Clinical Research, Foundation Chair of Clinical Cancer Research, University of Western Australia and Head of Medical Oncology at Sir Charles Gairdner Hospital, Perth, Australia. For additional information regarding the trial, please visit www.clinicaltrials.gov , NCT03053466. Genolimzumab Injection (CBT-501) CBT-501 is a novel humanized IgG4 monoclonal antibody targeting the Programmed Death-1 (PD-1) membrane receptor on T lymphocytes and other cells of the immune system. CBT-501 has a comparable efficacy profile in in vitro and in vivo studies to marketed anti-PD-1 antibodies and has a favorable safety profile with very low undesirable antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activity. The antibody (CBT-501, GB226) has been developed by Genor BioPharma Co. Ltd., a Walvax Company, who owns development and commercialization rights in China. CBT Pharmaceuticals, Inc. retains rest of the world (ROW) rights.

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